Matthew McConaughey is in talks with Don Cheadle to headline the actor’s directorial debut “Tishomingo Blues”. "Tishomingo Blues" is set in Mississippi, birthplace of the blues, and centers on Dennis Lenahan (McConaughey), a circus high diver staying at the Tishomingo Lodge & Casino who happens to witness a murder by local members of the Dixie Mafia. Robert Taylor (Cheadle), a slick con artist bent on taking over the mob’s drug business, also witnesses the crime. Lenahan and Taylor become friends, and through a series of events, the killers, drug-dealing cronies, shady businessmen and the con artist all find themselves performing in Lenahan’s Civil War re-enactment — but the ammunition may be real. The project, budgeted at $15 million, will go into production Sept. 2 says The Hollywood Reporter.