“Scream 3″ co-stars Neve Campbell and Patrick Dempsey reunite shortly on “Grey’s Anatomy”, with the former joining the series to play Derek’s mysterious sister.

The Hollywood Reporter has the first photo of Campbell as ‘Lizzie’.

Lizzie first arrives in the closing moments of the Dec. 6 hour, titled “Love Turns You Upside Down,” when Meredith (Ellen Pompeo) asks intern Heather (Tina Majorino) to go above and beyond to help fix her husband’s hand. Campbell will return the following week for the episode titled “Run Baby Run.”

Details about the nature of the Shepard siblings’ relationship are being kept under wraps, but Lizzie — who appears to be married judging by the ring on her finger in the image above — will return Dec. 13 for the “Run Baby Run” hour.

Wonder if Campbell’s presence will boost appealing in the long-running series?